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# CITATION file created with {cffr} R package
# See also: https://docs.ropensci.org/cffr/
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cff-version: 1.2.0
message: 'To cite package "getmstatistic" in publications use:'
type: software
license: MIT
title: 'getmstatistic: Quantifying Systematic Heterogeneity in Meta-Analysis'
version: 0.2.2
identifiers:
- type: doi
  value: 10.32614/CRAN.package.getmstatistic
abstract: 'Quantifying systematic heterogeneity in meta-analysis using R. The M statistic
  aggregates heterogeneity information across multiple variants to, identify systematic
  heterogeneity patterns and their direction of effect in meta-analysis. It''s primary
  use is to identify outlier studies, which either show "null" effects or consistently
  show stronger or weaker genetic effects than average across, the panel of variants
  examined in a GWAS meta-analysis. In contrast to conventional heterogeneity metrics
  (Q-statistic, I-squared and tau-squared) which measure random heterogeneity at individual
  variants, M measures systematic (non-random) heterogeneity across multiple independently
  associated variants. Systematic heterogeneity can arise in a meta-analysis due to
  differences in the study characteristics of participating studies. Some of the differences
  may include: ancestry, allele frequencies, phenotype definition, age-of-disease
  onset, family-history, gender, linkage disequilibrium and quality control thresholds.
  See <https://magosil86.github.io/getmstatistic/> for statistical statistical theory,
  documentation and examples.'
authors:
- family-names: Magosi
  given-names: Lerato E
  email: lmagosi@well.ox.ac.uk
- family-names: Hopewell
  given-names: Jemma C
  email: jemma.hopewell@ndph.ox.ac.uk
- family-names: Farrall
  given-names: Martin
  email: mfarrall@well.ox.ac.uk
- family-names: Magosi
  given-names: Lerato E
  email: magosil86@gmail.com
preferred-citation:
  type: article
  title: Identifying Systematic Heterogeneity Patterns in Genetic Association Meta-analysis
    Studies getmstatistic
  authors:
  - family-names: Magosi
    given-names: Lerato E.
  - family-names: Goel
    given-names: Anuj
  - family-names: Hopewell
    given-names: Jemma C.
  - family-names: Farrall
    given-names: Martin
    email: mfarrall@well.ox.ac.uk
  journal: Plos Genetics
  year: '2017'
  volume: '13'
  issue: '5'
  url: https://magosil86.github.io/getmstatistic/
  start: e1006755 https://doi.org/10.1371/journal.pgen.1006755
repository: https://magosil86.r-universe.dev
repository-code: https://github.com/magosil86/getmstatistic
commit: b99b362abef3fcd1488da6912c12f8e5cce58ed5
url: https://magosil86.github.io/getmstatistic/
contact:
- family-names: Magosi
  given-names: Lerato E
  email: magosil86@gmail.com